There are a number of clinical trials and studies on-going at New England Eye Center. If interested, please call the contact person listed for the specific trial or study.
Retina || Pediatrics || Cornea
Retina Studies
Dry AMD
PI: Michelle Liang, MD
Title: IMPACT/SWAGGER
Sponsor: Boston Image Reading Center
Inclusion Criteria
- Clinic diagnosis of non-exudative iAMD in at least one eye with a drusen volume in the central 3 mm circle centered on the fovea of at least 0.02 mm3 in the absence of GA or nGA.
- Clinical diagnosis of early or early/intermediate stage AMD in one eye in the absence of nGA or GA and exudative AMD in the other eye.
- Clinical diagnosis of GA or nGA secondary to AMD that is at least the size of a large druse (125 microns in diameter; 0.05 mm2) and no greater than 7 disc areas (17 mm2) in at least one eye which has never been treated with anti-VEGF agents.
Study Length and Visits: 9 Visits every three months over two years
Age Range: >50
Payment: $250 Total: [50$ at screening, V2,4,6 and 8]
Contact: Michael Dixon, 617-636-1051
Pseudophakic Cystoid Macular Edema
Primary Investigator: Elias Reichel, MD
Title: Subconjunctival Aflibercept injection for pseudophakic Cystoid Macular Edema
Sponsor: Regeneron
Inclusion Criteria
- Diagnosed with pseudophakic CME defined as central retinal thickness (CRT)>300 microns, presence of intraretinal cysts on optical coherence tomography (OCT) and visual acuity <=20/32 with petaloid leakage on fluorescein angiogram and late leakage at the disc.
- Diagnosed with “recalcitrant” CME, defined as less than a 15% decrease in CRT after at least 6 weeks of topical non-steroidal anti-inflammatory drug 3) Has had cataract surgery in the study eye with posterior chamber or anterior chamber intraocular lens implantation.
Study Length and Visits: 5 Visits: One baseline visit followed by three monthly visits (Months 1-3) and an end of study visit at Month 6.
Age Range: >18
Payment: None
Contact: Michael Dixon, 617-636-1051
Dry Age-Related Macular Degeneration
Primary Investigator: Andre Witkin, MD
Title: A Randomized, Double Masked, Placebo Controlled Study Evaluating ORACEA in Subjects with Geographic Atrophy Secondary to Non-Exudative Age-Related Macular Degeneration
Sponsor: University of VirginiaBrief Summary
This is a phase II study to assess the safety and effectiveness of oral doxycycline (ORACEA®), compared to placebo, to determine if it can slow the progression of geographic atrophy in patients who have dry age-related macular degeneration (AMD).
Inclusion Criteria
Clinical diagnosis of geographic atrophy secondary to dry age-related macular degeneration in at least one eye
Study Length and Visits: 6 study visits over a 25-month period with additional testing
Age Range: 55-85 years
Gender: Both
Payment: None
Contact: Study Coordinator, 617-636-1051
Pediatrics Studies
Pediatric Amblyopia
Primary Investigator: Vicki Chen, MD
Title: Novel Video Based Therapy for Children with Amblyopia
Inclusion Criteria
Group #1: Age 4-10 years, untreated or minimally treated amblyopia with possible need for patching/atropine, BCVA in amblyopic eye 20/30 to 20/80, 20/30 or better in fellow eye, no previous intraocular or refractive surgery, no coexisting ocular, neurological or systemic disease that could impact visual acuity assessment Group #2: Age 4-15 years, amblyopia, one or more other eye conditions with amblyopic component, BCVA in amblyopic eye 20/30 to 20/80, 20/30 or better in fellow eye
Risk: Minimal, including possible temporary headaches, double vision, eye strain timeframe
Benefit: Alternative treatment to patching/atropine, potential improvement in vision Study Length and Visits: 16 weeks, 4 visits (5 visits including enrollment visit)
Payment: None
Contact: Principal Investigator Dr. Vicki Chen, Co-Investigators Dr. Catherine Choi, Dr. Nicole Quinn, Dr. Sylvia Yoo, or Shelley Klein: 617-636-6769
OCTA in Amblyopic Eyes
Primary Investigator: Catherine Choi, MD
Title: Structural Changes in Optical Coherence Tomography Angiography (OCTA) in Amblyopic Eyes
Inclusion/Exclusion Criteria
Age 4-12 years with diagnosis of refractive, strabismic, or deprivation amblyopia
BCVA in amblyopic eye 20/30 or worse with 2 Snellen line difference from fellow, non-amblyopic eye
No previous intraocular or refractive surgery, no coexisting ocular, neurological or systemic disease, no history of prematurity > 8 weeksRisk: Minimal, including possible temporary eye strain and photophobia from dilating drops
Benefit: Enhance understanding of anatomic differences associated with amblyopia and assess whether structural changes occur with appropriate treatment
Study Length and Visits: 4 visits total over course of 1 year, at 3 month intervals
Payment: None currently (pending additional funding)
Contact: Principal Investigator Dr. Catherine Choi, Co-Investigators Dr. Vicki Chen, Dr. Nicole Quinn, Dr. David Reese, Dr. Sylvia Yoo, or Shelley Klein: 617-636-6769
Cornea Studies
Zoster Eye Disease Study (ZEDS)
PI: Kenneth Kenyon, MD
Title: A multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) in the year prior to enrollment.
Sponsor: NYU/NEI/NIH
Inclusion Criteria
- Ability to take oral medication, and are willing to adhere to study medication regimen.
- Diagnosed with HZO in one eye based on both of these criteria:
- History of characteristic unilateral vesicular rash in the dermatomal distribution of cranial nerve V1.
- Medical record documentation of an episode of active dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to HZO within the preceding year. This episode of active anterior segment ocular disease may be due to HZO of recent onset (within the preceding 6 months); or chronic HZO (with onset six or more months ago); may be new, worsening, or recurrent disease after a period of inactivity; and may occur after medication was reduced.
- For females with reproductive potential, willingness to use highly effective contraception (e.g., hormonal contraception, barrier contraception, intrauterine device, or abstinence).
Study Length and Visits: 8 Visits over 18 months
Age Range: >18
Payment: $50 for participation
Contact: Michael Dixon, 617-636-1051
Glaucoma Undergoing Cataracts Surgery
PI: Kamden Kopani, MD
Title: Analysis of the secretome in the aqueous humor from patients undergoing cataract surgery
Sponsor: Novartis
Inclusion Criteria
Patients diagnosed with open angle glaucoma and requiring cataract surgery.
Study Length and Visits: Collection during cataracts surgery
Age Range: 18-90
Payment: None
Contact: Michael Dixon, 617-636-1051